Applications are invited for two research studentships (one masters and one PhD) in the South African National Bioinformatics Institute (www.sanbi.ac.za).
Both research projects are computational projects and will focus on research of Human Immunodeficiency Virus (HIV).
HIV Transmission networks (MSc) Viral sequence data generated from a number of sources will be used to
undertake in-depth studies of transmission networks present within HIV infected populations. We will combine the use of phylogenetic methods together with available epidemiological information to model the extent of clustering present within these populations. This will be correlated with the presence of drug resistant mutations to describe the levels of transmission of resistant virus between individuals. This project will use currently available methodologies but will also, where necessary, involve the development of novel approaches.
Management and analysis of ultra-deep sequencing data (PhD) Recent advances in sequencing technologies mean that we are now able to sequence the level of HIV viral diversity present within an individual to
unprecedented levels. Such advances mean that new computational tools for managing and studying this data need to be developed. This project will involve developing methods to manage such large volumes of data but will also involve undertaking comprehensive analysis of novel data, particularly to document the presence and emergence of minor viral variants during disease progression and in response to antiretroviral treatment.
General information
MSc applicants should be in possession of a good Honours (BSc) degree (average score not less than 60%) in a related scientific subject area.
Candidates with an undergraduate degree or diploma (M +3) having at least 3-5 years experience will also be considered.
PhD applicants should be in possession of a Masters degree whether in Bioinformatics or in a related scientific field subject area such as Computer Science, Mathematics, Biochemistry, Engineering or other areas.
Applicants with an outstanding undergraduate degree may also be considered.
Applicants should have computational experience with proficiency in at least one programming language (C++, java, perl, python) being desirable for the MSc project and essential for the PhD project.
Please send a covering letter and comprehensive C.V. to Simon Travers, SANBI (simon@sanbi.ac.za)
Closing date for applications is 11th August 2010.
Both research projects are computational projects and will focus on research of Human Immunodeficiency Virus (HIV).
HIV Transmission networks (MSc) Viral sequence data generated from a number of sources will be used to
undertake in-depth studies of transmission networks present within HIV infected populations. We will combine the use of phylogenetic methods together with available epidemiological information to model the extent of clustering present within these populations. This will be correlated with the presence of drug resistant mutations to describe the levels of transmission of resistant virus between individuals. This project will use currently available methodologies but will also, where necessary, involve the development of novel approaches.
Management and analysis of ultra-deep sequencing data (PhD) Recent advances in sequencing technologies mean that we are now able to sequence the level of HIV viral diversity present within an individual to
unprecedented levels. Such advances mean that new computational tools for managing and studying this data need to be developed. This project will involve developing methods to manage such large volumes of data but will also involve undertaking comprehensive analysis of novel data, particularly to document the presence and emergence of minor viral variants during disease progression and in response to antiretroviral treatment.
General information
MSc applicants should be in possession of a good Honours (BSc) degree (average score not less than 60%) in a related scientific subject area.
Candidates with an undergraduate degree or diploma (M +3) having at least 3-5 years experience will also be considered.
PhD applicants should be in possession of a Masters degree whether in Bioinformatics or in a related scientific field subject area such as Computer Science, Mathematics, Biochemistry, Engineering or other areas.
Applicants with an outstanding undergraduate degree may also be considered.
Applicants should have computational experience with proficiency in at least one programming language (C++, java, perl, python) being desirable for the MSc project and essential for the PhD project.
Please send a covering letter and comprehensive C.V. to Simon Travers, SANBI (simon@sanbi.ac.za)
Closing date for applications is 11th August 2010.
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