A 3-year PhD scholarship is available at Centre for Microbial Biotechnology, Department of Systems Biology.
The project
LC-MS target metabolomics is the key word of this PhD project. By using different MS compatible HPLC methods for highly hydrophilic substances (HILIC-MS, IC –MS, and Ion-pair-MS) an efficient protocol for quantification of selected reporter metabolites will be developed. In addition, novel Solid Phase Extraction (SPE) protocols should be introduced to separate metabolite groups for better analytical chromatographic analysis. Finally, the project will target and validate quenching protocols for the CMB’s focus organisms covering yeasts, fungi and actinomycetes.
The project will start along with a metabolic flux analysis project, where focus is on upgrading the existing analytical platforms for supporting our research in quantitative microbial physiology and eukaryotic molecular biology.
Qualifications
The successful applicant should be a systematic highly independent team-player who is able to focus on finalizing things. We are looking for a candidate with a Master’s degree in chemistry or biochemistry with experience in liquid chromatography (especially ion-chromatography), and tandem mass spectrometry and/or accurate-mass mass spectrometry. Experience with GC-MS and derivatization as well as solid-phase extraction for sample purification will be appreciated. Knowledge on database searching and creation as well as multivariate statics is desirable. Overall IT skills and experience in programming will be appreciated.
Applicants should have a Master's degree in analytical chemistry, biochemistry, biotechnology or equivalent academic qualifications. In the assessment of the candidates, consideration will be given to:
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.
Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.
Further information
Further information can be obtained from Associate Professor Kristian Fog Nielsen, phone: + 45 4525 2602.
You can read more about DTU System Biology at www.cmb.bio.dtu.dk
Application
We must have your online application by 1 December 2010. Please open the link "apply for this job online", fill in the application form and attach the following documents:
All interested candidates irrespective of age, gender, race, religion or ethnic background are encouraged to apply.
The department of Systems Biology represents a large concentration of academic biotechnological research in Denmark, including protein and enzyme chemistry, food biochemistry, bioinformatics, systems biology, molecular biology, fermentation technology, physiology and genetics of industrial microorganisms and medical microbiology. The department hosts around 35 senior and 50 junior faculty members and post-doctoral fellows, 65 PhD students and 80 technical/administrative personnel. In addition to bachelor, master and PhD education, collaborative research and innovation together with national and international universities and industries is given high priority at the department.
Center for Microbial Biotechnology has 13 senior and 11 junior faculty and post-doctoral fellows and 25 PhD students as well as technical/administrative staff. The research is on industrial biotechnology, including fermentation, fungal biodiversity, heterologous expression of secondary metabolites in new hosts, mycotoxins, and metabolic engineering.
Apply for this job online
The project
LC-MS target metabolomics is the key word of this PhD project. By using different MS compatible HPLC methods for highly hydrophilic substances (HILIC-MS, IC –MS, and Ion-pair-MS) an efficient protocol for quantification of selected reporter metabolites will be developed. In addition, novel Solid Phase Extraction (SPE) protocols should be introduced to separate metabolite groups for better analytical chromatographic analysis. Finally, the project will target and validate quenching protocols for the CMB’s focus organisms covering yeasts, fungi and actinomycetes.
The project will start along with a metabolic flux analysis project, where focus is on upgrading the existing analytical platforms for supporting our research in quantitative microbial physiology and eukaryotic molecular biology.
Qualifications
The successful applicant should be a systematic highly independent team-player who is able to focus on finalizing things. We are looking for a candidate with a Master’s degree in chemistry or biochemistry with experience in liquid chromatography (especially ion-chromatography), and tandem mass spectrometry and/or accurate-mass mass spectrometry. Experience with GC-MS and derivatization as well as solid-phase extraction for sample purification will be appreciated. Knowledge on database searching and creation as well as multivariate statics is desirable. Overall IT skills and experience in programming will be appreciated.
Applicants should have a Master's degree in analytical chemistry, biochemistry, biotechnology or equivalent academic qualifications. In the assessment of the candidates, consideration will be given to:
- Experience in method development with hands on experience in mass spectrometry and chromatography as well as research potential
- Experience in quantitative analysis by LC-MS and/or GC-MS
- Experience on biochemical reactions, organic chemistry and fermentation
- IT skills including light programming
- The ability to collaborate as well as communicate, promote and utilize research results
- The ability to contribute to development of the department’s internal and external cooperation
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.
Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.
Further information
Further information can be obtained from Associate Professor Kristian Fog Nielsen, phone: + 45 4525 2602.
You can read more about DTU System Biology at www.cmb.bio.dtu.dk
Application
We must have your online application by 1 December 2010. Please open the link "apply for this job online", fill in the application form and attach the following documents:
- A letter motivating the application (cover letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma
- Conversion of grade averages to Danish grades (see guidelines and excel spreadsheet for the conversion here)
All interested candidates irrespective of age, gender, race, religion or ethnic background are encouraged to apply.
The department of Systems Biology represents a large concentration of academic biotechnological research in Denmark, including protein and enzyme chemistry, food biochemistry, bioinformatics, systems biology, molecular biology, fermentation technology, physiology and genetics of industrial microorganisms and medical microbiology. The department hosts around 35 senior and 50 junior faculty members and post-doctoral fellows, 65 PhD students and 80 technical/administrative personnel. In addition to bachelor, master and PhD education, collaborative research and innovation together with national and international universities and industries is given high priority at the department.
Center for Microbial Biotechnology has 13 senior and 11 junior faculty and post-doctoral fellows and 25 PhD students as well as technical/administrative staff. The research is on industrial biotechnology, including fermentation, fungal biodiversity, heterologous expression of secondary metabolites in new hosts, mycotoxins, and metabolic engineering.
Apply for this job online
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